Core Facilities
Introduction

The MRI facility, as a core facility of ICPBR, currently houses four high-field MRI systems, including a Tesla-Bruker 47/60 vertical system and three Bruker BioSpec horizontal systems (70/40 USR, 70/30 USR, and 94/30 USR). Together, they provide comprehensive technical coverage across experimental scales and species, from rodents to non-human primates (NHP).

The facility is supported by a highly qualified team of engineers who offer full-process technical support, encompassing experimental consultation and planning, operation training, image acquisition, post-processing, and data analysis services. It is dedicated to serving as key infrastructure driving forward‑cutting neuroscience research.

Tesla-Bruker 47/60 vertical system

The new and world-unique high-field vertical MRI system (Tesla-Bruker 4.7T, 60cm bore) has been installed. The commissioning and trial runs are in progress, and the system is expected to become fully operational for NHP neuroscience research soon.

The system's core advantage lies in its ability to perform awake functional MRI on large NHP in a seated, upright posture, closely mimicking their natural behavioral state. This capability holds significant importance for neurofunctional research, as it enables direct comparison between data from awake animals and human subjects, thereby advancing the interpretation of cross-species studies and driving progress in related human research.

Characterized by a 60‑cm large-bore design, the system can accommodate large and complex peripheral experimental setups, enabling multimodal functional imaging. This feature allows flexible integration with various advanced experimental approaches (e.g., neuromodulation techniques), supporting multiscale and multimodal neuroscience investigations. This significantly enhances experimental flexibility and enriches data dimensionality, playing a key supporting role in comprehensively elucidating brain function and the mechanisms of brain disorders.


Bruker BioSpec 70/40 USR horizontal system

This high-field horizontal MRI system, equipped with a Bruker 7T and 40-cm-bore magnet, is now in routine operation for NHP research. It supports scanning of anesthetized monkeys and enables structural MRI, diffusion imaging, resting-state and task-based functional MRI, as well as quantitative imaging methodologies. With its 40-cm large-bore design, the system can accommodate large monkeys weighing up to 12 kg, representing the first installation of its kind for animal imaging in China.

Bruker BioSpec 70/30 USR horizontal system

This high-field small-animal MRI system (Bruker 7.0T, 30 cm bore) is being deployed to support rodent studies and cross-species methodological validation.

Bruker BioSpec 94/30 USR horizontal system

Installation of an ultra–high-field small-animal MRI system (Bruker 9.4T, 30cm bore) is currently in progress and scheduled to be completed in the near future.

Contact

Dr. SHAO Tingting

Position: MRI Facility Manager

Email: tingting.shao@icpbr.ac.cn