Electrophysiology recording, as the ‘golden standard’ tools in the neuroscience, affords the advantages of high temporal resolution detection of the neural signal. However, the conventional neural interface has been limited by its instability caused by the mechanical mismatch between the rigid electrode and the soft brain tissue. The development of the ultraflexible neural interface has enabled a glial scare free chronic stable multichannel recording in the rodent model for over many months. Moreover, the combination of the ultraflexible neural interface with other advanced imaging methods has enabled new possibilities in the neuroscience study. And the application of the electrode in the spinal cord and peripheral nervous system potentially open new opportunities for clinical advances. Our group is focusing on the development of neural interfaces in both central and peripheral nervous systems.