High-resolution fMRI allows us to determine more accurately the origins of the fMRI signal. Here we compare the specificity of BOLD and CBV fMRI methods in the macaque at 4.7 and 7T; its striate cortex shows very obvious laminar structure in anatomical images, allowing accurate determination of the location of the fMRI activation. Highest spatial specificity is achieved using SE-based methods. No differences in specificity were observed between SE and SE-MION. The higher specificity of GE-MION over GE-BOLD can be mostly explained by the dropout of signal from larger vessels. The SNR benefits from MION decreased from 4.7T to 7T.