Abstract
A voice region has recently been identified in the monkey auditory cortex with functional magnetic resonance imaging (fMRI) and electrophysiology, which shows a close functional correspondence to the known human-voice region. Both human and monkey voice regions lie anterior and superior on the temporal lobe and strongly prefer species-specific vocalizations over other categories of sounds and acoustical controls. The human and monkey voice regions are also sensitive to vocal differences among individuals and appear to be important centers for vocal sound processing within a network that is poorly understood. To clarify the in-vivo functional connectivity of the voice region in the rhesus monkey we used microstimulation in combination with high-resolution fMRI. First we functionally localized the voice region with blood-oxygen-level-dependent (BOLD) fMRI, as previously described. Then we microstimulated the voice region with glass-coated iridium microelectrodes, using biphasic, cathode leading, 250 to 500 糀 pulses of 200 μs duration. We used the BOLD response to evaluate the anterograde targets of the microstimulation site. Microstimulation of the monkey voice region, which lies on the rostral superior-temporal plane (rSTP), elicited a BOLD response fr