Institute
Principal Investigators
LIU Zhen
  • Department:
  • Position:Principal Investigator
  • Research Field:Gene-modification technology and and genetic tools development for primate brain study
  • Phone:
  • E-mail:zhen.liu@icpbr.ac.cn
Biography

Dr. Zhen Liu graduated from Shandong Normal University with a B.S. degree in Biotechnology (2010) and received his Ph.D. degree in Neuroscience from the Institute of Neuroscience (ION), Chinese Academy of Sciences in 2017. After completing Ph.D., he continued postdoctoral research with Muming Poo and Qiang Sun in the Institute of Neuroscience (2017-2018). Dr. Liu joined ION as a Principal Investigator in September 2018.


Research Interests
1. Somatic cell nuclear transfer and cell reprogramming
2. Embryonic stem cell pluripotency
3. Germ cell differentiation and spermatogonia stem cell culture.
4. Genetic tools development for monkey brain study.


Selected Publications
1.Li, J., Zhu, Q., Cao, J., Liu, Y., Lu, Y., Sun, Y., Li, Q., Huang, Y., Shang, S.,Bian, X.,Li, C., Zhang, L.,Wang, Y., Nie, Y., Fu, J., Li, W., Mazid, M., Yu, J., Wen, J., Wang, J., Xiao,W., Sun, Y., EStban, M.,Sun, Q.*, Zhou, F.*, Liu, Z*. (2023) Cynomolgus monkey embryo model captures gastrulation and early pregnancy. Cell Stem Cell. 30(4): 362-377.E7.

2.Chen, H. Liu, X, Li, L., Tan, Q., Li, S., Li, L., Li, C., Fu, J., Lu, Y., Wang, Y., Sun, Y., Luo, Z.*, Lu, Z., Sun, Q.*, Liu, Z*. (2023) CATI: an efficient gene integration method for rodent and primate embryos by MMEJ suppression. Genome Biology. 24: 146

3.Zhu, W., Ding, Y., Meng, J., Gu, L., Liu, W., Li, L., Chen, H., Wang, Y., Li, Z., Li, C.*, Sun, Y.*, Liu, Z*. (2023) Reading and writing of mRNA m6A modification orchestrate maternal-to-zygotic transition in mice. Genome Biology. 67(2023).

4.Li, L., Liu, Z*. (2023) Genetic Approaches for Neural Circuits Dissection in Non-human Primates. Neuroscience Bulletin : In Press.

5.Lu, Z., He, S., Jiang, J., Zhuang, L., Wang, Y., Yang, G., Jiang, X., Nie, Y., Fu, J., Zhang, X., Lu, Y., Bian, X., Chang, H., Xiong, Z., Huang, X*., Liu, Z*., Sun, Q*. (2022) Base-edited cynomolgus monkeys mimic core symptoms of STXBP1 encephalopathy. Molecular Therapy. 30: 2163-2175.

6. Liu, Z*., Li, K., Cai, Y., Liu, Q., Zhang, T., Lu, Y., Nie, Y., Wang, Y., Yan, Z., Qu, Y., Li, Y., Wang, Z., Xiong, Z.*, Sun, Q.* (2021) Accelerated passage of gene-modified monkeys by hormone-induced precocious puberty. National Science Review. 10: 1093

7. Liu, Z., Cai, Y.,Wang, Y.,Wang, Z.,Jiang, X.,Li, Y.,Nie, Y.,Zhang, X.,Li, C.,Bian, X.,Poo, M.,Chang, H.*,Sun, Q.* (2019) Cloning of a Gene-edited Macaque Monkey by Somatic Cell Nuclear Transfer. National Science Review. 6: 101-108

8.Liu, Z., Cai, Y.,Wang, Y.,Nie, Y.,Zhang, C.,Xu, Y.,Zhang, X.,Lu, Y.,Wang, Z.,Poo, M.,Sun, Q.* (2018) Cloning of Macaque Monkeys by Somatic Cell Nuclear Transfer. Cell 172: 881-887

9. Liu, Z., Li, X.,Zhang, T.,Cai, Y.,Cheng, L.,Cheng, C.,Wang, Y.,Zhang, C.,Nie, Y.,Chen, Z.,Bian, W.,Zhang, L.,Xiao, J.,Lu, B.,Zhang, Y.,Zhang, X.,Sang, X.,Wu, J.,Xu, X.,Xiong, Z.,Zhang, F.,Yu, X.,Gong, N.,Zhou, W.,Sun, Q.*,Qiu, Z.* (2017) Autism-like behaviours and germline transmission in transgenic monkeys overexpressing MeCP2 . Nature 530: 98-102

10. Liu, Z., Nie, Y.,Zhang, C.,Cai, Y.,Wang, Y.,Lu, H.,Li, Y.,Cheng, C.,Qiu, Z.,Sun, Q.* (2015) Generation of macaques with sperm derived from juvenile monkey testicular xenografts. Cell Research. 26: 139–142