Dr. Angelovski has published a book chapter 2 entitled “Magnetic Resonance Imaging Bio-Sensors for Calcium(II)” in the book “Metal Ions in Life Sciences”, guest editor: Thomas J. Meade. This is volume 23 of the book series Metal Ions in Life Sciences (MILS, series editors: Astrid Sigel, Helmut Sigel, Eva Freisinger, Roland K.O. Sigel).
In this chapter, Dr. Angelovski provides an overview of MRI probes sensitive to calcium(II) that were developed until now. The summary of this chapter is nicely described by Dr. Mark Pagel (University of Texas MD Anderson Cancer Center, Houston, USA) in his Book review published in the Coordination Chemistry Reviews 478 (2023) 214994:
“In Chapter 2, Goran Angelovski has presented a compelling comparison of contrast agents for magnetic resonance imaging (MRI) that evaluate Ca2+. His review starts with an informative description of MRI methods that detect T1, T2, CEST, fluorinated and hyperpolarized MR agents. He then progresses through the evolution of Gd3+ and Mn2+ chelates that detect Ca2+ with T1 MRI; examples of nanoparticle and protein-based agents labeled with Fe3+, Mn2+, Gd3+, or 19F that are detected with T1 or T2 MRI; Eu3+ and Yb3+ chelates that change chemical exchange rates of labile amide protons after Ca2+ binding, and a Co2+ chelate and 19F-labeled agents that change chemical shift after Ca2+ binding as detected with CEST MRI; chelates of Gd3+, Dy3+ and Y3+ that change the T1 or T2 relaxation rates of 19F after Ca2+ binding; and hyperpolarized agents that change 15N or 13C chemical shifts when bound to Ca2+. The chapter includes examples of in vivo MRI studies with Ca2+-responsive probes, showing that in vivo Ca2+ imaging has become a robust research direction. The author concludes the chapter with an important discussion of practical challenges for biological studies and translation to biomedical use.”
G. Angelovski G. Angelovski. “Magnetic Resonance Imaging Bio-Sensors for Calcium(II)" Met. Ions Life Sci. 2022, 23, 23-50. doi: 10.1201/9781003229971-2. eBook ISBN: 9781003229971
